Linkage mapping of the porcine myelin basic protein gene to chromosome 1.
نویسندگان
چکیده
QTL mapping: The AW33 QTL was shown to be linked to microsatellite MCW0170, and the ST53 QTL was tightly linked to MCW0114, both markers located on GGA4. Our results demonstrate that these markers and therefore the associated QTLs, map within the GGA4q21–q22 and GGA4q11–12 regions, respectively. These results provide multiple entry points into the physical map and sequence of the chicken genome for identification of genes that might underlie QTLs. For example, MCW0114 maps near IDS, the iduronate-2-sulfatase gene, whose product is involved in heparin sulphate metabolism, and MCW0170 maps to a region containing well-known regulatory genes (KIT, CLOCK, EGF and two GABA receptor genes) and UGDH, also involved in glycosaminoglycan and heparin sulphate metabolism. Variation in these genes could possibly affect egg size and/or shell characteristics.
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ورودعنوان ژورنال:
- Animal genetics
دوره 36 2 شماره
صفحات -
تاریخ انتشار 2005